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The Ethiopian Public Health Institute provide Referral diagnostic and analytic laboratory service to the public. The polio laboratory is WHO accredited and provides laboratory support for the ongoing polio surveillance program.

Biological product such as anti rabies vaccine is produced and administrated to those exposed. Monitoring safety and efficacy of drugs, foods and beverage and water analysis for its potability are some of the activities of the institute.
The institute, through its designed favorable condition provides also facilities to Addis Ababa University MSc and MPH students to work on their thesis using data and samples generated by the project.